Sarangthem Indira Devi: Profile

Research

1.    Research theme photo

2.    Verticals involved

Microbial Resources

3. Research Area/Research Expertise

·         Microbial Diversity and Microbial Biotechnology

·         Microbial peptides and bioactive molecules against AMR and MDR pathogens

·         Agricultural Microbiology

·         Proteomics Genomics

·         Characterization of Industrial enzymes from Microbial Resources

4. Research Summary

A. CurrentResearch:

Exploration and microbial diversity study from different unexplored ecological niches of NE IndiaCharacterization and functional evaluation of the microbial populations for their possible utilization in agriculture, industrial and therapeutic applications

• NE region of India creates a wide array of habitats owing to its varied climate and diverse topographical conditions that support unique sets of microorganisms, which could be of immense economic and commercial value. Considering the current rapid anthropogenic changes in the environment and to protect from the excessive wild harvest, adequate ex situ preservation and maintenance of these microorganisms is indispensable for future research, development and applicationsinagricultural, industrial and therapeutic applications. Therefore, Microbial Repository Centre of IBSD has a total collection of approx. 65000bacterial and fungal cultures isolated from different unique ecological niches of NE India such as caves, hot spring, cold spring, high altitudes, sacred forest, fermented foods and beverages, lakes, forest, endophytes, epiphytes, mushrooms, and untouched ecosystems collected from the northeastern states of India. Molecular characterization and identification of these microbial isolates is under study. Screening of the functional activity for antimicrobial resistance and industrial enzymes is under process.

• As a part of the endophytic study, Paenibacillus peoriae IBSD35 isolated from a medicinal plant Piscidia sp., have shown broad-spectrum of antimicrobial activity against the representative test pathogensviz.E. coli ATCC 25922, Candida ablicans ATCC 10231 and Staphylococcus aureus ATCC 25923. BGCs were predicted from P. peoriae IBSD35 with AntiSMASH analysis. The activity remains stable even after treatment with degradative enzymes, detergents, and inorganic solvents. The enzyme was subjected to LC-MS analysis and confirmed the presence of predicted secondary metabolites and antibiotics gene clusters. The antimicrobial peptide was identified as 35.5 % similarity to Sakacin P (bacteriocin) with a molecular weight 5383.74 D. Moreover, from the KEGG pathway database analysis it confirms that the genome harbours type II polyketide biosynthesis which synthesized products like Dihydrokalafungin, oxytetracycline, tetracycline, nogalavinone, elloramycin and tetranomycin F. Further analysis and pathway study for the above enzyme is under process.It can be used as future antibiotics and foof preservatives
  

• Screening and characterization of industrially important enzymes from bacteria and fungi.
  
• Exploration and characterization of wild mushrooms from different districts of Manipur including a giant edible wild mushroomand screening of their nutritional and antimicrobial activity. Development of edible wild mushroom production technology.

   

B. Previous Notable Research:

·      Characterized potential rhizosphere Trichoderma sp. diversity and bacteria having PGPR and biocontrol properties against soil and seed borne pathogens

·      Charcterized antimicrobial peptides and bioactive metabolites against AMR pathogens from endophytes and soilmicroorganisms.

Publications:

Selected Research Articles

1. Sahoo D, Jusna N, Ngashangva N, Momota P, Rojeena Y, Indira S* 2019. Draft Genome Sequence of Arthrobacter globiformis mrc11, an Antimicrobial Agent Isolated from a Khangkhui Cave Deposit. Microbial Resource Announcement. 8: Issue 11. DOI: http://doi.org/10.1128/MRA.01620-18. PMID: 30938326  IF:
   
   
2. Phazna TA, Sahoo D, Indira S*, M.C Kalita, S Aravind 2019. Rhizobacterial isolates of Capsicum chinense inhibited fungal pathogen Rhizoctonia solani. International Journal of Scientific Research. 6:112-117. DOI: https://doi.org/10.26438/ijsrbs/v6i1.112117.
   
   
3.  Phazna TA, Sahoo D, Aravind S. Chandradev S, Indira S 2019.Bacterial rhizosphere community profile at different growth stages of Umorok (Capsicum chinense) and its response to the root exudates. Int Microbiol (2019). https://doi.org/10.1007/s10123-019-00097IF:  1.26
   
   
4. Melissa LT, Marshall JM, Cliff JB, Boasal RF, Dohnalkova AC, Dmitri M, Indira S, Olga VM, James B.H, David MW and Linda ST 2018. Phenazine-1-carboxylic acid and soil moisture influence biofilm development and turnover of rhizobacterial biomass on wheat root surfaces. Environmental Microbiology, doi:10.1111/1462-2920.14244. PMID: 29687554ISSN No. 1462-2920 IF- 5.4.
   
   
5. Momota P, Sahoo D, P.Verma, Verma S, Kalita MC, Indira S*. 2018. Draft Genome Sequence of Bacillus altitudinis Lc5, a Biocontrol and Plant Growth-Promoting Endophyte Strain Isolated from Indigenous Black Rice of Manipur. Genome Announcements. Vol 6, Issue 26, 1-2. PMID: 29954905ISSN No. 2169-8287  IF- 1.2
   
   
6. Indira S *, Lotjem H, Julia E, Momota P, Ngasangba Ng, J. Bora, Sahoo D, Sharma C. 2017. Biomining of the forest ecosystem of North East India for identification of antimicrobial metabolites from fungi through submerged fermentation. Bioresource Technology. 241: 1168-1172.  DOI:10.1016/j.biortech.2017.05.130ISSN No. 0960-8524 IF- 6.67
   
   
7. Momota P, Indira S*, Sahoo D, Strobel A 2017. Functional Chracterization o Endophytic Fungal Community Associated with Oryza sativa L. and Zea mays L. Frontiers in Microbiology. Vol.8.325. doi:10.3389 /fmicb.2017.00325. PMID: 28303127ISSN No.1664-302X IF- 4.1
   
   
8. Dubey SC, Tripathi A, Rakesh T, Indira S. 2017. Management of root rot and damping off complex in French bean by biocontrol agents. Indian Phytopath. 70 (3): 388-390 (2017) DOI 10.24838/ip.2017.v70.i3.72500  IF: 0.23
   
   
9. Kamala Th, Indira S *, Sharma K. C and Kennedy K 2015. Phylogeny and Taxonomical Investigation of Trichoderma spp. from Indian Region of Indo-Burma Biodiversity Hotspot Region with Special Reference to anipur. BioMed Research International. Vol. 15. Article ID 285261. PMID: 25699268ISSN No. 2169-8287 IF- 2.5
   
   
10. Paul P, Roy S, Sarkar S, Chowdhury S, Dutta RN, Raghavaiah PP, McArdle P, Dev L, Indira S. 2015. Synthesis, structure and properties of a manganese (II) benzoate containing diimine. Journal of Molecular Structure 1102. 153-160.  https://doi.org/10.1016/j.molstruc.2015.08.049  ISSN No. 0022-2860  IF- 1.7
    
    
11. Kamala TH, Indira S*, Gourshyam Th, Bharat, G.S. 2013. Genetic diversity and species pattern of Trichoderma and Hypocrea in Manipur using in-silico analysis. Bioinformation, 9(2), 106-111.  PMID: 23390355ISSN No. 0973-2063  IF-1.0
    
    
12. Devi R, Rana VS, Indira S. 2013. Mercedes Verdeguer and Maria Amparo Blazquez. 2012. Chemical composition and antimicrobial activity of the essential oil of Curcuma leucorhiza Roxb.  Journal of Essential Oil Research, 24(6), 533-538. DOI: 10.1080/10412905.2012.728089 ISSN No. 1041-2905  IF- 1.0
    
    
13. Kamala T,  Indira S* 2012. Biocontrol properties of indigenous Trichoderma isolates from NE India against Fusarium oxysporum and Rhizoctonia solani. African J of Biotechnology, 11(34):8491-8499. DOI: 10.5897/AJB11.1938ISSN No. 1684-5315  IF-0.8
    
    
14. Indira S*, Bharat S, Momota P, Talukdar NC. 2012. Genetic characterization of Burkholderia cepacia strain from Northeast vIndia: A potential bio-control agent. Advances in Bioscience and Biotechnioogy, 3, 1179-1188. http://dx.doi.org/10.4236/abb.2012.38144ISSN No. 2156-8456  IF-0.6
    
    
15. Indira S, Talukdar NC, Sharma C, Rohinikumar M 2011. Screening rhizobacteria for their plant growth promotion ability and antagonism against damping off and root rot diseases of broad bean (Viciafaba L.). Indian Journal of Microbiology, 51(1):14-21(Springer).  PMID: 22282623 ISSN No-004-8991 IF-2.9
    
    
16. Kamala TH, Indira S* 2011. Evaluation of indigenous Trichoderma isolates from Manipur as biocontrol agent against Pythium aphanidermatum on common beans. 3Biotech. 1: 217-225. Springer.  PMID: 22558540ISSN No. 2190-5738  IF- 1.3
    
    
17. Indira S, Vashista P, Sharma CB. 2005. Purification to homogeneity & Characterization of the antifungal protein from the roots of Arachies hypogeae L., National Academy of Science Letters, vol.28, No. 1&2. ISSN No. 2250-1754IF:0.6

1. Kamala TH and Indira S* 2012. Prospect of Trichoderma as a potential fungicide. Int. Journal of Human Genetics Medical Biotech and Microbiol. Studies, 1(3), 1-10. ISSN No. 0972-3757

B.      Book Chapters :

1. Indira S, Momota P. 2015. “Plant –Endophyte Interaction and Its Unrelenting Contribution Towards Plant Health” in Plant Microbes Symbiosis: Applied Facets. Chapter7, page 147-162,  Springer, IndiaDOI 10.1007/978-81-322-2068-8_7

Group Members (Details):

Research Grants/Projects

A.     Core/Internal

a.      Present:

B.      Extramural:

a.         Present:

  Past: