Dr. Asamanja Chattoraj,Scientist-D
Area of Research
Cellular and Molecular Chronobiology of Fish Reproduction and Physiology
At present, there are two emerging models regarding the relationship between the central and peripheral clock mechanism-“master-slave” and “orchestra”. According to the “master-slave” model the peripheral clocks are synchronized solely by the central clock and are not otherwise affected by the external or internal stimuli. On the other hand, according to the “orchestra” model central clock behaves like a conductor to each peripheral clock as an orchestra member. Our research is mainly focused on the influence of environmental factors on temporal pattern of body functions and their synchronization. Our finding support the “orchestra” phenomenon in establishing a relationship with the central and peripheral systems in reference to the environmental photo-thermal conditions.
Several life style diseases are emerging from the loss of synchronization between environmental cues and body functioning. We are trying to address this loss of rhythm with special emphasis on clock associated genes and the chronobiotic molecule “melatonin” using fish as model.
Core Funded Research Project:
Chronobiology of fish gut microflora and melatonin.
Melatonin as Bioindicator for Oocyte Maturation in Fish.
Zebrafish as a model on bio-rhythm studies with special emphasis on reproduction.
On Going Externally Funded Research Grant:
DST-SERB Fast Track Young Scientist From December 2013.
Unit of Excellence on Chronobiology in North East From June 2014.
PhD: Visva-Bharati, Santiniketan, West Bengal, India
Post-doctoral Research Fellow in the Medical School, University of Michigan, USA.Post-doctoral
Research Fellow in Graduate School of Nursing & School of Medicine: Department of Biochemistry and Molecular Biology Uniformed Services University of the Health Sciences, Bethesda, USA.
Awards & Fellowships
Membership in Reproduction and Endocrinology, by the Society of Reproductive Biology and Comparative Endocrinology-2016
Prof. MA Akbarsha Oration Award, for the contribution in endocrinology by the Society of Reproductive Biology and Comparative Endocrinology-2015
Executive committee member of the Society for Reproductive Biology and Comparative Endocrinology.
Member of the Society for Research on Biological rhythm.
Three Important Publications Based on the Contribution in the Field
Melatonin biosynthesizing enzyme genes and clock genes in ovary and whole brain of zebrafish (Danio rerio): Differential expression and a possible interplay, Gen. Comp. Endocrinol. (2016) May 11; 233:16-31.
Melatonin formation in mammals: in vivo perspectives. REMD .10: 237-243 (2009).
Melatonin Accelerates Maturation Inducing Hormone (MIH)–Induced Oocyte Maturation in Carps. Gen Comp Endocrinol 140: 145-155 (2005).
Publications in Chronobiology of Reproduction and Physiology
Melatonin: A potent candidate in the regulation of ﬁsh oocyte growth and maturation, Gen. Comp. Endocrinol. 15:215-222 (2013).
Photoinduction and Reproduction. (2011). Lambart Publication. Saarbrucken Germany. ISBN: 978-3-8433-9225-9.
Posttranscriptional regulation of pineal melatonin synthesis in Octodon degus. J Pineal Res. 47:75–81 (2009).
The increased degradation of NAT-H28Y mutant protein is due to a reduced interaction with 14-3-3. J Pineal Res. 46:119–120 (2009).
Posttranslational regulation of TPH1 is responsible for the nightly surge of 5-HT output in the rat pineal gland. J Pineal Res. 45:506–514 (2008).
Temporal relationship between the circulating profiles of melatonin and ovarian steroids under natural photo-thermal conditions in an annual reproductive cycle in carp Catla catla. Biol. Rhythm Res. 40: 347-359 (2009).
Localization and dynamics of Mel (1a) melatonin receptor in the ovary of carp Catla catla in relation to serum melatonin levels. Comp Biochem Physiol A, 152:327-333 (2009).
Influence of serotonin on the action of melatonin in MIH-induced meiotic resumption in the oocytes of carp Catla catla. Comp Biochem Physiol A, 150: 301-306 (2008).
Role of photoperiod and melatonin in the regulation of ovarian functions in Indian carp Catla catla: Basic information for future application. Fish Physiol Biochem 33: 367-382 (2007).
Melatonin in the regulation of annual testicular events in carp Catla catla: evidence from the studies on the effects of exogenous melatonin, continuous light and continuous darkness.” Chronobiol Internl 24:629-650 (2007).
Implication of melatonin in oocyte maturation in Indian major carp (Catla catla). Fish Physiol Biochem 31: 201-207 (2005).
Photoperiod, pineal photoreceptors and melatonin as the signal of photoperiod in the regulation of reproduction in fish. J Endocrinol Reprod 10: 73-87 (2006).
The pineal organ and reproduction in fish. Proc Zool Soc 59: 35-60 (2006).
Ultrastructural and Morphometric Study of the Pineal Complex in Indian Major Carp Catla catla in Response to Continuous Light and Darkness. J Endocrinol Reprod 9: 1-10 (2005).
Publications in other fields of Biology
Rhinovirus Delays Cell Repolarization in a Model of Injured/Regenerating Human Airway Epithelium, Am J Respir Cell Mol Biol. (2016) Apr 27
Rhinovirus-induced barrier dysfunction in polarized airway epithelial cells is mediated by NADPH oxidase 1. J Virol 85: 6795-808 (2011).
Quercetin prevents progression of disease in elastase/LPS-exposed mice by negatively regulating MMP expression. Respir Res. 11: 131 (2010)
Arsenic-induced changes in optic tectal histoarchitecture and acetylcholinesterase-acetylcholine profile in Channa punctatus: amelioration by selenium. Comp Biochem Physiol C 144:16-24 (2006).
Biological Rhythm Laboratory Group
|Mrs. Haobijam Sanjita Devi, PhD-JRF, CSIR-JRF, GATEEmail: email@example.comExtension Number: 289Problem Addressing: Fish gut melatonin: Regulation and Synthesis.|
|Mr. Chongtham Rajiv, PhD-JRF, CSIR-JRF, GATEEmail: firstname.lastname@example.orgExtension Number: 289Problem Addressing: Extra-pineal sources of melatonin and its regulation in fish.|
|Mr. Zeeshan Ahmad Khan, PhD-JRF, DBT JRF, NET, GATEEmail: email@example.comExtension Number: 289Problem Addressing: Clock genes and regulation of reproduction in Zebra fish.|
|Mr. Thangal Yumnamcha, RA (Project), SLETEmail: firstname.lastname@example.orgExtension Number: 289Problem Addressing: Pathways of action of melatonin in fish oocyte development and maturation|
|Mr. Gopinath Mondal, DST-JRF (Project), GATE, CSIR-NETEmail: email@example.comExtension Number: 289Problem Addressing: Interaction between clock genes and reproductive hormones in fish reproduction.|
|Ms. Sijagurumayum Dharmajyoti Devi, DBT-JRF (Project), ICAR NET, GATEEmail: firstname.lastname@example.orgExtension Number: 289Problem Addressing: Clock genes and fish gut melatonin, a possible regulatory mechanism.|
|Mr. Rahul Wakambam, Lab Assistant (DBT Project)Email: email@example.comExtension Number: 289|
|1.||Mr. Bishorjit Hijam, Lab Assistant|
|2.||Mr. L. Umakanta Singh, Lab Assistant|
|3.||Mr. Sorokhaibam Surjit Singh, Lab Technician|
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